He was born on Long Island.
In 1948 Plastino showed samples of his work to editors at DC and began a 20-year stint on the Superman family of books. At first he was required to mimic Wayne Boring's style but as time went on he was allowed to draw like Al Plastino. The worked on Superman, Superboy, and Lois Lane. With Otto Binder he co-created Supergirl and The Legion of Super-Heroes.
Plastino also drew the Superman newspaper strip in the late 60s and the Batman strip from 1966-1972. When DC ousted him from their books in 1968 Al Plastino also took over the Ferd'nand newspaper strip which he drew until he retired in 1989. In 1983 he drew the Sunday episodes of Nancy after Ernie Bushmiller died and he also drew a year's worth of Peanuts strips in the early 1980s to be used if Charles Schulz became ill.
Plastino died on November 25, 2013, at the age of 91. 
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- Al Plastino's Images as a Penciler
- Al Plastino's Images as an Inker
- Al Plastino's Images as a Cover Artist