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History of character is unknown.
- Medicine: Doctor Spence helped developed the Cadmus technology that was used to pod, house and especially heal the various live clones or experiments that dwell within her employment.
- Science: Doctor Spence is one of the head doctors in charge of both the Superboy and Match projects.
- Amanda Spence was voiced by Vanessa Marshall.
- 4 Appearances of Amanda Spence (Earth-16)
- 1 Images featuring Amanda Spence (Earth-16)
- Quotations by or about Amanda Spence (Earth-16)
- Character Gallery: Amanda Spence (Earth-16)