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Big City was the 1940s base of operations for the young adventurers, Little Boy Blue and the Blue Boys.
- Big City may have been the site of a fight between Superboy and Risk. A waste disposal dumpster at the scene of the fight identifies Big City, though this does not necessarily mean that this is where the fight took place. 
- Another city called "Big City" was featured in National Comics #42 as the home of Carnie Calahan. That city is located in Pennsylvania.