The Brain and his assistant Monsieur Mallah are behind an experiment to use mind-control collars on India's wildlife, which he had enhanced into enlarged monsters using Kobra Venom. The Team went to investigate and Captain Marvel was captured, Brain tried to surgically remove Captain Marvel's brain to see what effects "the wisdom of Solomon" had on it. The Team defeats the mutated animals by removing their mind-control collars. The team then manages to find a way into Brain's lair whith the help of Wolf and Mr. Tawny and defeat them, but Brain and Monsieur Mallah end up getting away. It is later revealed that Brain is L-6 of The Light.
- The Brain appears in the Young Justice voiced by Nolan North in the first appearance and by Corey Burton in the second appearance.
- 17 Appearances of Brain (Earth-16)
- 1 Images featuring Brain (Earth-16)
- Quotations by or about Brain (Earth-16)
- Character Gallery: Brain (Earth-16)
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