This section of the history takes place during Flashpoint, a massive crossover event set in an alternate timeline to the mainstream DCU. History was completely changed when Professor Zoom finally found a way to erase his nemesis the Flash without harming his own legacy.
In the Flashpoint timeline, Joe Chill murders Bruce Wayne, rather than the boy's parents. Martha Wayne was so traumatized by the event she cuts open her cheeks to create a faux smile. Months after the murder, Martha tracks Chill down and murders him with a hammer. She turns to crime, working with her own version of Harley Quinn called Yo-Yo and becoming the archenemy of her husband, Batman.
Martha later kidnaps the twin children of Judge Dent, and tricks Chief Gordon into shooting Dent's daughter by taping her mouth shut and guns to her hands, and disguising her as the Joker. After Gordon does the deed, she slashes the chief's throat. Batman turns up to face his estranged wife.  Thomas tells her he has discovered a way to rewrite history so Bruce was never killed, and about Barry Allen and how he helped him restore his powers. Martha, however, is shocked that her son will grow up to become her greatest enemy, and commits suicide off a cliff near Wayne Manor. 
- 8 Appearances of Martha Kane (Flashpoint Timeline)
- 2 Images featuring Martha Kane (Flashpoint Timeline)
- 1 Quotations by or about Martha Kane (Flashpoint Timeline)
- Character Gallery: Martha Kane (Flashpoint Timeline)