The Science and Technology Advanced Research Laboratories, usually shortened to S.T.A.R. Labs, was a research organization founded by a scientist named Garrison Slate, who wanted a nationwide chain of research laboratories unconnected to the government or any business interests.
He succeeded not only on a national scale, but an international one as well: S.T.A.R. Labs maintained facilities in Canada, Europe, Australia, and Japan as well as in the United States, with the total number of facilities numbering between twenty and thirty at last recorded count.
Lex Luthor has attempted to buy out S.T.A.R. on at least one occasion. The technology used to maintain Cyborg's mechanical parts comes from S.T.A.R. Labs. These parts were also used to create cybernetic enhancements for Ron Evers.
The central branch in Metropolis is most likely one of the more recognizable branches, due to its connection with Superman and the various supervillains they hold. During the Armageddon 2001 event, the Metropolis branch was destroyed in the fight between Captain Atom and Monarch, but as since been rebuilt. As well, S.T.A.R. Labs offered help during the time when the Sun-Eater extinguished the sun.
A partial list of some known locations of S.T.A.R. Labs facilities and their research focuses where known includes:
- Austin, Texas (Silicone Hills): specializing in A.I., genetics, and metahuman studies.
- Central City, Missouri
- Chicago, Illinois: specializing in research and technology
- Gotham City: specializing in weaponry
- Keystone City, Kansas
- Los Angeles, California: specializing in genetics and disease control
- Melbourne, Australia
- Metropolis (Queensland Park Borough, near Metropolis Harbor): specializing in marine biology
- Metropolis (central branch, New Troy Island): catch-all facility, often seen as a temporary holding area for captured supervillains, as research is made on how to contain them.
- New York City: specializing in research and technology
- Phoenix, Arizona: specializing in meteorology and natural disasters
- Salt Lake City, Utah: 
- San Diego, California: specializing in chemical research
- San Francisco, California: specializing in studying meta-humans
- Seattle, Washington: specializing in studying psychology and psionics.
- Wichita, Kansas: specializing in computer engineering
Among the dismantled or otherwise inactive facilities:
Equipment: Various scientific equipment
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- Appearances of S.T.A.R. Labs (Chronological)
- Appearances of S.T.A.R. Labs
- Organization Gallery: S.T.A.R. Labs
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