The villains of Wonder Woman are a diverse bunch, and range from thieves to spies to gods. The majority of her foes are women, and the only "official" union, Villainy, Inc., is all-female, though Doctor Psycho has a long history of teaming up with other villains.
- Angle Man: a thief who uses a special "Angler" that can alter angles and cause people to lose their balance.
- Baroness Paula Von Gunther: a Nazi spy, she successfully reformed and joined the Amazons as one of their chief physicians.
- Cheetah: Priscilla Rich and Deborah Domaine are catsuit-wearing thieves; Barbara Minerva and Sebastian Ballesteros are cat-like cratures empowered by Urzkartaga, the plant god.
- Circe: the witch of Aeaea and a powerful sorceress. Main villain in War of the Gods and Who is Wonder Woman?.
- Dark Angel: the Donna Troy of Earth-Seven, a witch whose life goal it is to torture Donna.
- Decay: a tool of Ares.
- Devastation: an Anti-Wonder Woman, created by Cronus in much the same way Wonder Woman was, and empowered by his children.
- Doctor Cyber: a powerful crimeboss who suffers from body dysmorphic disorder and hides her scarred face behind a mask.
- Doctor Psycho: a dwarf with mind control powers and hatred of women - Wonder Woman in particular.
- Duke of Deception: for a long time, the primary agent of Ares. Often aided by the Earl of Greed and Count of Conquest.
- Genocide: a powerful, soulless warrior created by the Society, empowered by the Lasso of Truth.
- Mask: Nina Close, a victim of domestic violence who lashed out against her husband and other abusive husbands.
- Medusa: the powerful Gorgon who could turn people to stone.
- Nikos Aegeus: a warrior empowered by Bellerophon.
- Osira: an alien masquerading as an Egyptian queen.
- Queen of Fables: an extradimensional sorceress who mistook Wonder Woman for her mortal enemy Snow White.
- Shim'Tar : the champion of the Bana-Mighdall; while later incarnations were allies, initially they were enemies.
- Silver Swan: a name used by three women - Helen Alexandros, Valerie Beaudry and Vanessa Kapatellis - who were all exploited due to their low self-esteem over their appearance.
- Veronica Cale: a self-made millionnaire who, like Lex Luthor to Superman, hates Wonder Woman who was born with the privilege of powers.
- White Magician: the main antagonist of Artemis during her brief tenure as Wonder Woman, a wizard who created several other monster-of-the-week villains before facing her himself - which led to both their deaths.
- Queen Clea: exiled queen from a minor Atlantean kingdom
- Doctor Poison: a Japanese princess and expert of toxicology. Her granddaughter later took over the mantle.
- Blue Snowman: a woman in a snowman-suit that appears male.
- Eviless: Queen of Saturn.
- Giganta: a strongwoman, later granted the power to change her size at will.
- Hypnota: a sideshow hypnotist.
- Zara: Self-styled "priestess of the Crimson Flame", a former child-slave who set up a cult around her - faked - ability to wield flames.
- Cyborgirl: the niece of Sarah Charles, a former drug addict who had most of her body replaced by cybernetics:
- Jinx: primarily a Teen Titans villain, the Indian sorceress later joined the female villain-team.
- Trinity: a virus bent on destruction.
- The Circle: a group of disgraced Amazons, former Queen's guards Myrto, Charis, Philomela and Alkyone.
- Gods of Olympus: several Gods have, at one time or another, opposed Wonder Woman, though they may be portrayed as allies at an earlier (or later) point.
- Ares: the God of War, Ares or Mars is one of Wonder Woman's oldest villains, and directly responsible for most of the Amazons' history. Over the years, he has empowered many others to become villains as well.
- Hades: the God of the Underworld, Hades or Pluto is usually portrayed as benevolent but neutral, though he has plotted against Wonder Woman as well.
- Hera: In the New 52, Hera briefly opposed Wonder Woman as the princess was a bastard child of her husband Zeus.
- Children of Ares: Ares sired many children (including Hippolyta), and several opposed Diana and the Amazons. The name itself is used for five boys who were born to Amazons through mysterious virgin births.
History of rogues gallery activity is unknown.
Equipment: None known.
Transportation: None known.
Weapons: None known.
- No special notes.
- No trivia.