Zambesi is an African country that has been through years of violence and suffers from lawlessness and poaching. It was, for a long time, run by dictator Mustapha Maksai, who killed his half-brother Richard Jiwe in a heated race for presidency. Jiwe's daughter, superhero Vixen, later avenged him.
- Vixen's home country was initially called D'Mulla, but it was later changed to M'Changa. This eventually evolved into "the Zambesi nation" and later just Zambesi. The Vixen webseries addresses this discrepancy by making M'Changa a province of Zambesi.
- The exact location is unclear. It is usually described as Central African, but also in the shadow of Mount Kilimanjaro in Tanzania as well as on the slave coast of West Africa. The Zambesi River is an actual river in East Africa (flowing through Zambia and Zimbabwe). Mustapha Maksai's last name is Swahili (East African). The Tantu Totem draws from Ashanti folklore and Yoruba animism.